A label-free electrochemical strategy for highly sensitive methyltransferase activity assaysElectronic supplementary information (ESI) available: TEM and AFM images of graphene, and detailed experimental methods. See DOI: 10.1039/c5cc00658a

A new electrochemical strategy for the simple and ultrasensitive evaluation of DNA methyltransferase (MTase) activity was developed based on electrocatalytic oxidation of ascorbic acid by graphene. In addition, the suitability of this sensing platform for MTase inhibitor screening was also demonstrated. A label-free strategy for evaluation of DNA methyltransferase activity was developed based on electrocatalytic oxidation of ascorbic acid by graphene.