Pd-catalyzed oxidative C-H alkenylation for synthesizing arylvinyltriazole nucleosidesElectronic supplementary information (ESI) available: Experimental details, analytical data and spectra of all synthesized compounds. See DOI: 10.1039/c4ob01836b

Various arylvinyltriazole nucleoside analogues were synthesized using Pd-catalyzed oxidative Heck reaction. This method affords the corresponding and otherwise difficult to achieve arylvinyltriazole nucleosides with good yields and large functional group compatibility. These results further advocate the potential and practicality of this oxidative C-H alkenylation method for generating structurally challenging chemical entities in organic synthesis. Pd-catalyzed oxidative C-H alkenylation: an effective method for synthesizing arylvinyltriazole nucleosides in good yields and with large functional group tolerance.