Synthesis and LC-MS/MS analysis of desmosine-CH2, a potential internal standard for the degraded elastin biomarker desmosineElectronic supplementary information (ESI) available: 1H and 13C NMR spectra for synthetic compounds. See DOI: 10.1039/c4ob01438c

Desmosine-CH 2 , an analog of the elastic tissue degradation biomarker desmosine, can be regarded as a potential internal standard for precise quantification of desmosines by LC-MS/MS. In this study, the chemical synthesis of desmosine-CH 2 was completed in 22% overall yield in five steps. The LC-MS/MS analysis of desmosine-CH 2 was also achieved. Chemical synthesis and LC-MS/MS analysis of desmosine-CH 2 , a potential internal standard for the degraded elastin biomarker desmosine, are achieved.