Influence of water-soluble derivatives of [60]fullerene on therapeutically important targets related to neurodegenerative diseasesElectronic supplementary information (ESI) available. See DOI: 10.1039/c4md00194j

We report the investigation of the molecular mechanisms responsible for the neuroprotective activity of water-soluble [60]fullerene derivatives (WS[60]FDs). It has been shown that WS[60]FDs influence the therapeutically important targets of the Alzheimer disease by inhibiting the catalytic activity of the monoaminooxidase B in vitro , decreasing the level of free radical species and behaving as positive modulators of AMPA receptors of Purkinje neurons in the cerebellum of rats. The cognitive stimulatory effects of WS[60]FDs were revealed in vivo through behavioural experiments in mice. Water soluble fullerene derivatives I and II were shown to behave as promising neuroprotective agents that improve cognitive functioning in animals.