Melting point-solubility-structure correlations in multicomponent crystals containing fumaric or adipic acidElectronic supplementary information (ESI) available. CCDC 1008278-1008281. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c4ce01298d

This study investigates the relationships between the supramolecular structure and the solubility and melting point of six multicomponent crystals involving fumaric acid (FUM series) and adipic acid (ADI series). The crystals were prepared by solvent evaporation and fully characterised by thermal and diffraction techniques. In each series the melting points of the multicomponent crystals are lower than the relevant carboxylic acid and they show partial correlation with their aqueous solubilities. With the aid of Hirshfeld surface analysis, the relationships between solubility, melting point and the supramolecular structure are discussed. The relationships between the melting point, solubility and structure was investigated in a series of multicomponent crystals of fumaric and adipic acid.