Construction of anti-parallel G-quadruplexes through sequential templated clickElectronic supplementary information (ESI) available: Experimental procedures and characterisation. See DOI: 10.1039/c4cc09744k

Biologically relevant DNA sequences were assembled onto addressable cyclopeptide scaffolds through sequential oxime and CuAAc reactions. The resulting conjugates are able to fold into well-defined anti-parallel DNA G-quadruplex structures, which exhibit high stability and reduced polymorphism. Biologically relevant anti-parallel DNA G-quadruplexes were constrained and stabilised onto addressable cyclopeptide scaffolds through sequential oxime and CuAAc reactions.