A metal-based tumour necrosis factor-alpha converting enzyme inhibitorElectronic supplementary information (ESI) available: Experimental details. See DOI: 10.1039/c4cc09251a
We report herein a novel iridium( iii ) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells. We report herein a novel iridium( iii ) complex 1 as an...
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| creator | Leung, Chung-Hang Liu, Li-Juan Lu, Lihua He, Bingyong Kwong, Daniel W. J Wong, Chun-Yuen Ma, Dik-Lung |
| description | We report herein a novel iridium(
iii
) complex
1
as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex
1
inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells.
We report herein a novel iridium(
iii
) complex
1
as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. |
| doi_str_mv | 10.1039/c4cc09251a |
| format | Article |
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iii
) complex
1
as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex
1
inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells.
We report herein a novel iridium(
iii
) complex
1
as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c4cc09251a</identifier><language>eng</language><creationdate>2015-02</creationdate><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Leung, Chung-Hang</creatorcontrib><creatorcontrib>Liu, Li-Juan</creatorcontrib><creatorcontrib>Lu, Lihua</creatorcontrib><creatorcontrib>He, Bingyong</creatorcontrib><creatorcontrib>Kwong, Daniel W. J</creatorcontrib><creatorcontrib>Wong, Chun-Yuen</creatorcontrib><creatorcontrib>Ma, Dik-Lung</creatorcontrib><title>A metal-based tumour necrosis factor-alpha converting enzyme inhibitorElectronic supplementary information (ESI) available: Experimental details. See DOI: 10.1039/c4cc09251a</title><description>We report herein a novel iridium(
iii
) complex
1
as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex
1
inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells.
We report herein a novel iridium(
iii
) complex
1
as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity.</description><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqFjzFPwzAQhS0EEqWwsCMdGwwuCUmg6YZKKjoxlIEtujgXauTYlu1UlP_Ef8SgSgxI8JY76X16d4-x0zSZpElWXolciKS8LlLcY6M0u8l5kU-f97_2ouS3WV4csiPvX5OotJiO2Mcd9BRQ8QY9tRCG3gwONAlnvPTQoQjGcVR2jSCM3pALUr8A6fdtTyD1WjYyEpUiEZzRUoAfrFXUkw7otpHojOsxSKPholotLwE3KBU2imZQvVly8htV0MY3pPITWBHB_eNyBr9LHbODDpWnk90cs7NF9TR_4M6L2saoeLL-wbMxO__Lr23bZf9lfAJfNWxu</recordid><startdate>20150219</startdate><enddate>20150219</enddate><creator>Leung, Chung-Hang</creator><creator>Liu, Li-Juan</creator><creator>Lu, Lihua</creator><creator>He, Bingyong</creator><creator>Kwong, Daniel W. J</creator><creator>Wong, Chun-Yuen</creator><creator>Ma, Dik-Lung</creator><scope/></search><sort><creationdate>20150219</creationdate><title>A metal-based tumour necrosis factor-alpha converting enzyme inhibitorElectronic supplementary information (ESI) available: Experimental details. See DOI: 10.1039/c4cc09251a</title><author>Leung, Chung-Hang ; Liu, Li-Juan ; Lu, Lihua ; He, Bingyong ; Kwong, Daniel W. J ; Wong, Chun-Yuen ; Ma, Dik-Lung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-rsc_primary_c4cc09251a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leung, Chung-Hang</creatorcontrib><creatorcontrib>Liu, Li-Juan</creatorcontrib><creatorcontrib>Lu, Lihua</creatorcontrib><creatorcontrib>He, Bingyong</creatorcontrib><creatorcontrib>Kwong, Daniel W. J</creatorcontrib><creatorcontrib>Wong, Chun-Yuen</creatorcontrib><creatorcontrib>Ma, Dik-Lung</creatorcontrib></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leung, Chung-Hang</au><au>Liu, Li-Juan</au><au>Lu, Lihua</au><au>He, Bingyong</au><au>Kwong, Daniel W. J</au><au>Wong, Chun-Yuen</au><au>Ma, Dik-Lung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A metal-based tumour necrosis factor-alpha converting enzyme inhibitorElectronic supplementary information (ESI) available: Experimental details. See DOI: 10.1039/c4cc09251a</atitle><date>2015-02-19</date><risdate>2015</risdate><volume>51</volume><issue>19</issue><spage>3973</spage><epage>3976</epage><pages>3973-3976</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>We report herein a novel iridium(
iii
) complex
1
as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex
1
inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells.
We report herein a novel iridium(
iii
) complex
1
as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity.</abstract><doi>10.1039/c4cc09251a</doi><tpages>4</tpages></addata></record> |
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| source | Royal Society Of Chemistry Journals; Alma/SFX Local Collection |
| title | A metal-based tumour necrosis factor-alpha converting enzyme inhibitorElectronic supplementary information (ESI) available: Experimental details. See DOI: 10.1039/c4cc09251a |
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