A metal-based tumour necrosis factor-alpha converting enzyme inhibitorElectronic supplementary information (ESI) available: Experimental details. See DOI: 10.1039/c4cc09251a

We report herein a novel iridium( iii ) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity. Complex 1 inhibited TNF-α secretion and p38 phosphorylation in human monocytic THP-1 cells. We report herein a novel iridium( iii ) complex 1 as an antitumour necrosis factor agent and the first metal-based inhibitor of TACE enzymatic activity.