A modular DNA origami-based enzyme cascade nanoreactorElectronic supplementary information (ESI) available: Experimental details, additional TEM image of dimer formation, progress curves for DNA origami units, DNA origami designs and DNA strand sequences. See DOI: 10.1039/c4cc08472a

In this communication, we present a nanoscale reactor assembled from tuneable and spatially addressable tubular DNA origami units. We can controllably combine separate origami units equipped with glucose oxidase (GOx) and horseradish peroxidase (HRP), and demonstrate efficient GOx/HRP enzyme cascade reaction inside the tube. The reactor could be utilized as a nanoscale diagnostic tool, and modularity of the proposed system would further enable more complex reactions. In this communication, we present a nanoscale reactor assembled from tuneable and spatially addressable tubular DNA origami units.