Ultrasensitive SERS assay of lysozyme using a novel and unique four-way helical junction molecule probe for signal amplificationElectronic supplementary information (ESI) available: Experimental procedures and additional figures. See DOI: 10.1039/c4cc08141b

A unique four-way helical junction molecule (FHJM) probe was ingeniously designed, and firstly introduced into DNA signal amplification as a novel Surface-enhanced Raman scattering (SERS) probe. Significantly, a new FHJM-SERS method was successfully developed for lysozyme detection with high sensitivity and specificity. A unique four-way helical junction molecule (FHJM) probe was ingeniously designed, and firstly introduced into DNA signal amplification as a novel Surface-enhanced Raman scattering (SERS) probe.