Synthesis and immunological evaluation of self-adjuvanting MUC1-macrophage activating lipopeptide 2 conjugate vaccine candidatesElectronic supplementary information (ESI) available: Full synthetic procedures, characterisation of novel compounds and immunological methods and data. See DOI: 10.1039/c4cc03510k

We describe herein the synthesis and immunological evaluation of self-adjuvanting mucin 1 (MUC1)-macrophage activating lipopeptide 2 (MALP2) (glyco)peptide vaccine candidates. Vaccine constructs were shown to induce high titres of class-switched IgG antibodies in C57BL/6 mice after four immunisations despite the lack of a helper T cell epitope. The synthesis and immunological evaluation of self-adjuvanting cancer vaccine candidates comprising of mucin 1 (MUC1) (glyco)peptides linked to macrophage activating lipopeptide 2 (MALP2) is described.