An ensemble of aptamers and antibodies for multivalent capture of cancer cellsElectronic supplementary information (ESI) available. See DOI: 10.1039/c4cc02002b

We developed an optimized ensemble of aptamers and antibodies that functions as a multivalent adhesive domain for the capture and isolation of cancer cells. When incorporated into a microfluidic device, the ensemble showed not only high capture efficiency, but also superior capture selectivity at a...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Zhang, Jinling, Sheng, Weian, Fan, Z. Hugh
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:We developed an optimized ensemble of aptamers and antibodies that functions as a multivalent adhesive domain for the capture and isolation of cancer cells. When incorporated into a microfluidic device, the ensemble showed not only high capture efficiency, but also superior capture selectivity at a high shear stress (or high flow rate). We created multivalent binding surfaces on microfluidic channels using an ensemble of aptamers and antibodies for capturing cancer cells.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc02002b