An ensemble of aptamers and antibodies for multivalent capture of cancer cellsElectronic supplementary information (ESI) available. See DOI: 10.1039/c4cc02002b
We developed an optimized ensemble of aptamers and antibodies that functions as a multivalent adhesive domain for the capture and isolation of cancer cells. When incorporated into a microfluidic device, the ensemble showed not only high capture efficiency, but also superior capture selectivity at a...
Gespeichert in:
Hauptverfasser: | , , |
---|---|
Format: | Artikel |
Sprache: | eng |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | We developed an optimized ensemble of aptamers and antibodies that functions as a multivalent adhesive domain for the capture and isolation of cancer cells. When incorporated into a microfluidic device, the ensemble showed not only high capture efficiency, but also superior capture selectivity at a high shear stress (or high flow rate).
We created multivalent binding surfaces on microfluidic channels using an ensemble of aptamers and antibodies for capturing cancer cells. |
---|---|
ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/c4cc02002b |