PEGylated aza-BODIPY derivatives as NIR probes for cellular imaging

Neutral water-soluble aza-dipyrromethene boron difluoride (aza-BODIPY) derivatives are synthesized for biological imaging applications. Aqueous solubility is increased by optimizing the synthetic conditions to obtain aza-BODIPYs with several tetraethyleneglycol groups. Their spectral properties and assays performed on cultured cells, demonstrate the potential of these compounds as near-infrared (NIR) emitting fluorescent probes. Neutral water-soluble aza-BODIPYs are synthesized for imaging applications, demonstrating their potential as NIR emitting fluorescent probes.