Voltage-responsive micelles based on the assembly of two biocompatible homopolymersElectronic supplementary information (ESI) available: supplementary characterization data. See DOI: 10.1039/c3py01204b

Voltage stimulus is considered as a clean and simple method in the field of stimuli-responsive polymer systems, in which the system based on β-cyclodextrin (β-CD) and ferrocene (Fc) has attracted considerable attention. Herein, we report voltage-responsive micelles based on the assembly of two bioco...

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Hauptverfasser: Peng, Liao, Feng, Anchao, Zhang, Huijuan, Wang, Hong, Jian, Chunmei, Liu, Bowen, Gao, Weiping, Yuan, Jinying
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Sprache:eng
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Zusammenfassung:Voltage stimulus is considered as a clean and simple method in the field of stimuli-responsive polymer systems, in which the system based on β-cyclodextrin (β-CD) and ferrocene (Fc) has attracted considerable attention. Herein, we report voltage-responsive micelles based on the assembly of two biocompatible homopolymers, namely, the poly(ethylene glycol) homopolymer modified with β-CD (PEG-β-CD) and the poly( l -lactide) homopolymer modified with Fc (PLLA-Fc). Through host-guest interactions between β-CD and Fc, the two homopolymers connect together, forming a non-covalent supramolecular block copolymer PLLA-Fc/PEG-β-CD. PLLA-Fc/PEG-β-CD can further self-assemble to form stable micelles in aqueous solution. Through electrochemical control, a reversible assembly-disassembly transition of this micellar system was realized. Voltage-controlled drug release based on this system was also conducted successfully. Two biocompatible homopolymers, PEG-β-CD and PLLA-Fc, were synthesized. The controlled assembly and disassembly of PLLA-Fc/PEG-β-CD micelles was successfully realized by applying a voltage stimulus.
ISSN:1759-9954
1759-9962
DOI:10.1039/c3py01204b