(+)-Fluorenylethylchloroformate (FLEC) - improved synthesis for application in chiral analysis and peptidomimetic synthesisElectronic supplementary information (ESI) available: Full experimental details relating to all syntheses are available as supplementary data. See DOI: 10.1039/c3ob40218e

An efficient synthesis of the enantiomers of fluorenylethylchloroformate (FLEC) has been achieved that allows the routine application of the reagent for the resolution of chiral amines including unusual amino acids. The utility of the fluorenylethoxycarbonyl (Feoc) group as a chiral Fmoc equivalent, for combined resolution and protection of amino acids, in solid phase peptide synthesis is also shown. The synthesis and application of a chiral Fmoc-equivalent (FLEC) has been achieved for combined resolution and protection of unusual amino acids for use in solid phase peptide synthesis.