Total synthesis of high loading capacity PEG-based supports: evaluation and improvement of the process by use of ultrafiltration and PEG as a solventElectronic supplementary information (ESI) available: Examples of calculation of green metrics for compounds 1, 19, and 15; 1H, 13C and MALDI TOF spectra for all compounds; Excel data sheet of the calculations. See DOI: 10.1039/c3gc37097f

The present work deals with the total synthesis of high loading capacity PEG supports with attention focused on improving the greenness of all the steps. The systematic calculation of green metrics offers an opportunity to evaluate the greenness and then to improve the process. To evidence such an improvement, the evaluation of the optimized processes was compared with that of the classical ones. Improvements in high loading capacity (up to 1.7 mmol g −1 ) PEG supports synthesis were implemented after green metrics calculation.