Supramolecular dynamics

Supramolecular systems are reversible and their dynamics is an inherent and essential property. The conceptual framework for kinetic studies of these systems is presented with a focus on the considerations required for experimental design. Selected examples for guest binding to cyclodextrins, cucurbit[ n ]urils, DNA, serum albumins and bile salt aggregates are presented that describe the type of information obtained from dynamic studies that are not available from thermodynamic investigations. The conceptual framework for the kinetic studies to characterize the dynamics of supramolecular systems is described.