Incorporation by coordination and release of the iron chelator drug deferiprone from zinc-based metal-organic frameworksElectronic supplementary information (ESI) available: CCDC 952363-952365 and 958616. Synthetic details, deferiprone release studies, X-ray structural analysis. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c3cc45689g

A series of new zinc-based metal-organic framework materials has been prepared in which deferiprone is incorporated as a chelating ligand on infinite or tri-zinc secondary building units following deprotonation. Deferiprone is immediately released from the MOFs on treatments with 1 N hydrochloric acid or buffer, but slow release is observed in ethanoic acid. A series of new zinc-based metal-organic framework materials has been prepared in which deferiprone (Hdfp) is incorporated as a chelating ligand.