Thiolated 2-methacryloyloxyethyl phosphorylcholine for an antifouling biosensor platformElectronic supplementary information (ESI) available: Synthesis and characterization of MPC-SH, SAM formation and characterization; and protein and cell measurements. See DOI: 10.1039/c3cc44357d

We developed a new building block for a protein- and cell-repellant self-assembled monolayer (SAM) from 2-methacryloyloxyethyl phosphorylcholine (MPC) via a simple Michael-type addition to one mercapto group in alkanedithiol. The thiolated MPC can enable functionalization of a noble metal electrode to minimize noise signal in biosensing. Formation of a MPC-SH SAM resists nonspecific protein adsorption and cell adhesion on a gold electrode.