Suzuki cross-couplings of (hetero)aryl chlorides in the solid-state

The ultrasound-assisted cross-linking of chitosan with hexamethylene diisocyanate with the simultaneous incorporation of Pd(OAc) 2 resulted in a catalyst which is suitable for the solid-state Suzuki cross-coupling of poorly reactive (hetero)aryl chlorides with phenylboronic acid. Reactions were carried out solvent-free in a planetary ball mill allowing the catalyst to be recycled several times. Mechanochemical activation enables solvent-free Suzuki cross-couplings of (hetero)aryl chlorides catalyzed by HMDI-chitosan/Pd II .