Towards a monomeric structure of phenylboronic acid: The influence of ortho-alkoxy substituents on the crystal structureElectronic supplementary information (ESI) available. It contains a full list of bond lengths, bond angles and torsion angles of the experimentally studied systems (1)-(6). It also contains symmetry, absolute electronic energy at MP2/631+G and B3LYP/6311+G (in Hartree) and Cartesian coordinates at MP2/631+G and B3LYP/6311+G levels for the molecules studied. The detailed data re

The structures of three ortho -alkoxyphenylboronic acids (2-methoxy-, 2-ethoxy-, 2-isobutoxy-), and three di ortho -alkoxyphenylboronic acids (2,6-dimethoxy-, 2,6-diethoxy- and 2-isobutoxy-6-methoxy) were determined by single crystal X-ray diffraction. The study was undertaken with the intention of designing a novel boronic acid having a monomeric structure, which to date has been an unavailable building block for crystal engineering. This motif can be enhanced by involving two hydroxyl groups at the boron atom in intramolecular hydrogen bonds. Although monosubstituted systems form typical dimers in the crystal lattice, disubstituted species reveal a much bigger variety of possible interactions. Among the analyzed compounds, 2,6-dimethoxyphenylboronic acid and 2,6-diethoxyphenylboronic acid crystallize in two polymorphic forms each. The unprecedented packing with monomers as the dominant structural motif has been found in the crystal structure of 2-isobutoxy-6-methoxyphenylboronic acid and one of the polymorphs of both 2,6-dimethoxyphenylboronic acid and 2,6-diethoxyphenylboronic acid. This description of the molecular packing is also supported by the analysis of fingerprint 2-D plots based on the Hirshfeld surfaces. The variety of possible types of interactions either within a single moiety or between moieties in dimers were additionally analyzed on the basis of the interaction energies, which have been estimated by ab initio calculations at the MP2/6-31+G* and B3LYP/6-311+G** level of theory. Novel building blocks for crystal engineering based on boronic acids having monomeric structure have been devised.