Catalysis-based enantioselective total synthesis of myxothiazole Z, (14S)-melithiazole G and (14S)-cystothiazole FElectronic supplementary information (ESI) available: Details of experimental procedures and 1H NMR, 13C NMR spectra for all new compounds. See DOI: 10.1039/c2cc35721f

A common strategy for the stereoselective and protecting group-free total synthesis of the myxobacterial antibiotics myxothiazole Z, (14 S )-melithiazole G and (14 S )-cystothiazole F is described featuring an asymmetric organocatalytic transfer hydrogenation, a palladium-catalyzed Stille coupling and a cross-metathesis as the key steps. A common strategy for the stereoselective total synthesis of the myxobacterial antibiotics myxothiazole Z, melithiazole G and cystothiazole F is described featuring an asymmetric organocatalytic transfer hydrogenation, a palladium-catalyzed Stille coupling and a cross-metathesis as the key steps.