In silico design, synthesis and evaluation of 3-O-benzylated analogs of salacinol, a potent -glucosidase inhibitor isolated from an Ayurvedic traditional medicine "Salacia"Electronic supplementary information (ESI) available: Experimental procedures for 7k and 13k, and their 1H and 13C NMR spectra. See DOI: 10.1039/c2cc34144a
With the aid of an in silico method, -glucosidase inhibitors with far more potent activities than salacinol ( 1 ), a potent natural -glucosidase inhibitor isolated from an Ayurvedic traditional medicine Salacia reticulata , have been developed. With the aid of an in silico method, -glucosidase inhib...
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| creator | Tanabe, Genzoh Nakamura, Shinya Tsutsui, Nozomi Balakishan, Gorre Xie, Weijia Tsuchiya, Satoshi Akaki, Junji Morikawa, Toshio Ninomiya, Kiyofumi Nakanishi, Isao Yoshikawa, Masayuki Muraoka, Osamu |
| description | With the aid of an
in silico
method, -glucosidase inhibitors with far more potent activities than salacinol (
1
), a potent natural -glucosidase inhibitor isolated from an Ayurvedic traditional medicine
Salacia reticulata
, have been developed.
With the aid of an
in silico
method, -glucosidase inhibitors (
7
) with far more potent activities than salacinol (
1
), a potent natural -glucosidase inhibitor isolated from an Ayurvedic traditional medicine
Salacia reticulata
, have been developed. |
| doi_str_mv | 10.1039/c2cc34144a |
| format | Article |
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in silico
method, -glucosidase inhibitors with far more potent activities than salacinol (
1
), a potent natural -glucosidase inhibitor isolated from an Ayurvedic traditional medicine
Salacia reticulata
, have been developed.
With the aid of an
in silico
method, -glucosidase inhibitors (
7
) with far more potent activities than salacinol (
1
), a potent natural -glucosidase inhibitor isolated from an Ayurvedic traditional medicine
Salacia reticulata
, have been developed.</description><identifier>ISSN: 1359-7345</identifier><identifier>EISSN: 1364-548X</identifier><identifier>DOI: 10.1039/c2cc34144a</identifier><language>eng</language><creationdate>2012-08</creationdate><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27913,27914</link.rule.ids></links><search><creatorcontrib>Tanabe, Genzoh</creatorcontrib><creatorcontrib>Nakamura, Shinya</creatorcontrib><creatorcontrib>Tsutsui, Nozomi</creatorcontrib><creatorcontrib>Balakishan, Gorre</creatorcontrib><creatorcontrib>Xie, Weijia</creatorcontrib><creatorcontrib>Tsuchiya, Satoshi</creatorcontrib><creatorcontrib>Akaki, Junji</creatorcontrib><creatorcontrib>Morikawa, Toshio</creatorcontrib><creatorcontrib>Ninomiya, Kiyofumi</creatorcontrib><creatorcontrib>Nakanishi, Isao</creatorcontrib><creatorcontrib>Yoshikawa, Masayuki</creatorcontrib><creatorcontrib>Muraoka, Osamu</creatorcontrib><title>In silico design, synthesis and evaluation of 3-O-benzylated analogs of salacinol, a potent -glucosidase inhibitor isolated from an Ayurvedic traditional medicine "Salacia"Electronic supplementary information (ESI) available: Experimental procedures for 7k and 13k, and their 1H and 13C NMR spectra. See DOI: 10.1039/c2cc34144a</title><description>With the aid of an
in silico
method, -glucosidase inhibitors with far more potent activities than salacinol (
1
), a potent natural -glucosidase inhibitor isolated from an Ayurvedic traditional medicine
Salacia reticulata
, have been developed.
With the aid of an
in silico
method, -glucosidase inhibitors (
7
) with far more potent activities than salacinol (
1
), a potent natural -glucosidase inhibitor isolated from an Ayurvedic traditional medicine
Salacia reticulata
, have been developed.</description><issn>1359-7345</issn><issn>1364-548X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqFUD1PwzAQDQgkysfCjnR0AqkpDUnox4ZKoB2gEmVgq67OpTV17ch2KsKvx0krMSCBl3u69-69O3veedBpB52wf8NuGQujIIpw32sE4V3kx1Hv_aDCcd_vhlF85B0b89FxL4h7jb2nsQTDBWcKUjJ8IVtgSmmXDhtAmQJtUBRouZKgMgj9iT8n-VUKtJQ6AQq1MBVjUCDjUokWIOTKkrTgL0TBlOEpGgIul3zOrdLAjdqOZ1qtnQfcl4XeUMoZWI0pr8JQwLrqcEnQnNbe2EwEMauVdEJT5LmgtUtBXTrvTOn1dsurZDq-BtwgFzgXNIDkMyfNa6mAXCtGaaHJgBuB7qo-MghXrRq4w7mGYLTrDuHl-RVMXsViG6ZE8DAZD-D3d596hxkKQ2e7euJdPCZvw5GvDZvlLt6tOfuRh__zl3_xszzNwm_itaCr</recordid><startdate>20120801</startdate><enddate>20120801</enddate><creator>Tanabe, Genzoh</creator><creator>Nakamura, Shinya</creator><creator>Tsutsui, Nozomi</creator><creator>Balakishan, Gorre</creator><creator>Xie, Weijia</creator><creator>Tsuchiya, Satoshi</creator><creator>Akaki, Junji</creator><creator>Morikawa, Toshio</creator><creator>Ninomiya, Kiyofumi</creator><creator>Nakanishi, Isao</creator><creator>Yoshikawa, Masayuki</creator><creator>Muraoka, Osamu</creator><scope/></search><sort><creationdate>20120801</creationdate><title>In silico design, synthesis and evaluation of 3-O-benzylated analogs of salacinol, a potent -glucosidase inhibitor isolated from an Ayurvedic traditional medicine "Salacia"Electronic supplementary information (ESI) available: Experimental procedures for 7k and 13k, and their 1H and 13C NMR spectra. See DOI: 10.1039/c2cc34144a</title><author>Tanabe, Genzoh ; Nakamura, Shinya ; Tsutsui, Nozomi ; Balakishan, Gorre ; Xie, Weijia ; Tsuchiya, Satoshi ; Akaki, Junji ; Morikawa, Toshio ; Ninomiya, Kiyofumi ; Nakanishi, Isao ; Yoshikawa, Masayuki ; Muraoka, Osamu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-rsc_primary_c2cc34144a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanabe, Genzoh</creatorcontrib><creatorcontrib>Nakamura, Shinya</creatorcontrib><creatorcontrib>Tsutsui, Nozomi</creatorcontrib><creatorcontrib>Balakishan, Gorre</creatorcontrib><creatorcontrib>Xie, Weijia</creatorcontrib><creatorcontrib>Tsuchiya, Satoshi</creatorcontrib><creatorcontrib>Akaki, Junji</creatorcontrib><creatorcontrib>Morikawa, Toshio</creatorcontrib><creatorcontrib>Ninomiya, Kiyofumi</creatorcontrib><creatorcontrib>Nakanishi, Isao</creatorcontrib><creatorcontrib>Yoshikawa, Masayuki</creatorcontrib><creatorcontrib>Muraoka, Osamu</creatorcontrib></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanabe, Genzoh</au><au>Nakamura, Shinya</au><au>Tsutsui, Nozomi</au><au>Balakishan, Gorre</au><au>Xie, Weijia</au><au>Tsuchiya, Satoshi</au><au>Akaki, Junji</au><au>Morikawa, Toshio</au><au>Ninomiya, Kiyofumi</au><au>Nakanishi, Isao</au><au>Yoshikawa, Masayuki</au><au>Muraoka, Osamu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>In silico design, synthesis and evaluation of 3-O-benzylated analogs of salacinol, a potent -glucosidase inhibitor isolated from an Ayurvedic traditional medicine "Salacia"Electronic supplementary information (ESI) available: Experimental procedures for 7k and 13k, and their 1H and 13C NMR spectra. See DOI: 10.1039/c2cc34144a</atitle><date>2012-08-01</date><risdate>2012</risdate><volume>48</volume><issue>69</issue><spage>8646</spage><epage>8648</epage><pages>8646-8648</pages><issn>1359-7345</issn><eissn>1364-548X</eissn><abstract>With the aid of an
in silico
method, -glucosidase inhibitors with far more potent activities than salacinol (
1
), a potent natural -glucosidase inhibitor isolated from an Ayurvedic traditional medicine
Salacia reticulata
, have been developed.
With the aid of an
in silico
method, -glucosidase inhibitors (
7
) with far more potent activities than salacinol (
1
), a potent natural -glucosidase inhibitor isolated from an Ayurvedic traditional medicine
Salacia reticulata
, have been developed.</abstract><doi>10.1039/c2cc34144a</doi><tpages>3</tpages></addata></record> |
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| title | In silico design, synthesis and evaluation of 3-O-benzylated analogs of salacinol, a potent -glucosidase inhibitor isolated from an Ayurvedic traditional medicine "Salacia"Electronic supplementary information (ESI) available: Experimental procedures for 7k and 13k, and their 1H and 13C NMR spectra. See DOI: 10.1039/c2cc34144a |
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