Fully automated sequential solid phase approach towards viral RNA-nucleopeptidesNucleic acids: new life, new materials' web themed issue.Electronic supplementary information (ESI) available: Synthetic procedures and 31P-NMR, 1H-NMR and LCMS-analysis of compounds 1 and 2. See DOI: 10.1039/c2cc33477a

The synthesis of two ribonucleoprotein fragments of unprecedented complexity is reported. These hybrid biomolecules are prepared combining the use of an automated solid phase peptide and oligonucleotide synthesizer on a single solid support. Preparation of ribonucleoprotein fragments of unprecedented complexity comprising solid-phase peptide and reverse RNA synthesis on a single solid support.