Synthesis of tetrahydro--carbolines via isomerization of N-allyltryptamines: a metal-catalyzed variation on the PictetSpengler themeElectronic supplementary information (ESI) available: Experimental procedures, characterization data for all substrates and products. See DOI: 10.1039/c2cc17704h
An efficient and broadly applicable alternative to the classical PictetSpengler synthesis of tetrahydro--carbolines is presented. The method relies on metal-catalyzed isomerization of allylic amines to form reactive iminium intermediates which can be trapped by a tethered indole nucleophile. A metal...
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | An efficient and broadly applicable alternative to the classical PictetSpengler synthesis of tetrahydro--carbolines is presented. The method relies on metal-catalyzed isomerization of allylic amines to form reactive iminium intermediates which can be trapped by a tethered indole nucleophile.
A metal-catalyzed alternative to the classical PictetSpengler synthesis of tetrahydro--carbolines is presented. The method relies on isomerization of allylic amines to form reactive iminium intermediates which react with a tethered indole nucleophile. |
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ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/c2cc17704h |