Coercing bisphosphonates to kill cancer cells with nanoscale coordination polymersElectronic supplementary information (ESI) available: Experimental procedures, X-ray crystallographic data, SEM and TEM images, IC50 values, and confocal images. CCDC 856980 and 856981. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c2cc17635a
Nanoscale coordination polymers containing exceptionally high loadings of bisphosphonates were coated with single lipid bilayers to control the drug release kinetics and functionalized with a targeting ligand to endow cell-targeting capability, leading to much enhanced cytotoxicity against human lun...
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