Coercing bisphosphonates to kill cancer cells with nanoscale coordination polymersElectronic supplementary information (ESI) available: Experimental procedures, X-ray crystallographic data, SEM and TEM images, IC50 values, and confocal images. CCDC 856980 and 856981. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c2cc17635a

Nanoscale coordination polymers containing exceptionally high loadings of bisphosphonates were coated with single lipid bilayers to control the drug release kinetics and functionalized with a targeting ligand to endow cell-targeting capability, leading to much enhanced cytotoxicity against human lung and pancreatic cancer cells. Nanoscale coordination polymers containing high loadings of bisphosphonates were coated with single lipid bilayers and functionalized with a targeting ligand to give enhanced cytotoxicity against human lung and pancreatic cancer cells.