A synergistic approach to anion antiportElectronic supplementary information (ESI) available: Details of membrane transport studies and graphs showing change in internal chloride concentration for compound 5. See DOI: 10.1039/c1dt10213c

A synergistic approach to Cl − /HCO 3 − antiport has been demonstrated in POPC lipid bilayers using an ion selective electrode assay showing that, when using combinations of carriers each optimised for a particular component of the transport process, enhanced rates of transport are observed. The use of combinations of carriers each optimised for a particular component of a chloride/bicarbonate antiport process results in a synergistic enhancement of transport rates.