Structure-activity studies of the pelorusides: new congeners and semi-synthetic analoguesElectronic supplementary information (ESI) available: NMR data for compounds 5 and 6, 1D- and 2D-NMR spectra and biological activity data for compounds 1 and 3-6. See DOI: 10.1039/c0ob01127d

Two new peloruside congeners ( 3 and 4 ) were isolated from wild and aquacultured collections of the New Zealand marine sponge Mycale hentscheli . Small-scale reactions on peloruside A ( 1 ) have been performed, which along with the isolation of 3 and 4 , give further insight into the bioactive pharmacophore of 1 . New naturally occurring and semi-synthetic pelorusides from the marine sponge Mycale hentscheli provide insight into the pharmacophore.