Tandem driven dynamic self-inhibition of acetylcholinesteraseThis article is part of the 'Enzymes and Proteins' web-theme issue for ChemComm.Electronic supplementary information (ESI) available: Experimental details, NMR spectra, inhibition studies. See DOI: 10.1039/c0cc02479a

A concept of tandem driven dynamic self-inhibition is demonstrated through dynamic inhibitors of acetylcholinesterase (AChE) using reversible transthiolesterification. A concept of tandem driven dynamic enzyme self-inhibition is demonstrated for acetylcholinesterase through the action of dynamic stealth inhibitors using reversible transthiolesterification.