Synthesis of phosphonamidate peptides by Staudinger reactions of silylated phosphinic acids and estersThis article is part of the 'Emerging Investigators' themed issue for ChemComm.Electronic supplementary information (ESI) available: General synthetic procedures, synthesis and characterisation of compounds. See DOI: 10.1039/c0cc02472dThis paper is dedicated to Prof. Helmut Vorbrüggen on the occasion of his 80th birthday

The Staudinger reaction of unprotected azido-peptides with silylated phosphinic acids and esters on the solid support offers a straightforward acid-free entry to different phosphonamidate peptide esters or acids under mild conditions in high purity and yield. The Staudinger reaction of unprotected azido-peptides with silylated phosphinic acids and esters on the solid support offers a straightforward acid-free entry to different phosphonamidate peptide esters or acids under mild conditions in high purity and yield.