Synthesis of MUC1-lipopeptide chimerasElectronic supplementary information (ESI) available: Experimental procedures and full spectroscopic data for new compounds. See DOI: 10.1039/c0cc01360a

An efficient method for the convergent assembly of MUC1-lipopeptide vaccine candidates is described. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the T N and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam 3 CysSer were synthesised in high yields using a fragment-based condensation strategy. Chimeras consisting of MUC1 glycopeptides (bearing multiple copies of the T N and T tumour-associated carbohydrate antigens) tethered to the lipopeptide immunoadjuvant Pam 3 CysSer were synthesised in high yields using a fragment-based condensation strategy.