A copper radiopharmaceutical for diagnostic imaging of Alzheimer's disease: a bis(thiosemicarbazonato)copper(ii) complex that binds to amyloid-β plaquesElectronic supplementary information (ESI) available: Experimental details. See DOI: 10.1039/c0cc01175d

A bis(thiosemicarbazonato)copper( ii ) complex with an appended stilbene functional group binds to amyloid-β plaques that are associated with Alzheimer's disease. The complex has the potential to be of use as a copper-64 radiopharmaceutical to assist in the diagnosis of Alzheimer's disease...

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Hauptverfasser: Lim, SinChun, Paterson, Brett M, Fodero-Tavoletti, Michelle T, O'Keefe, Graeme J, Cappai, Roberto, Barnham, Kevin J, Villemagne, Victor L, Donnelly, Paul S
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Sprache:eng
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Zusammenfassung:A bis(thiosemicarbazonato)copper( ii ) complex with an appended stilbene functional group binds to amyloid-β plaques that are associated with Alzheimer's disease. The complex has the potential to be of use as a copper-64 radiopharmaceutical to assist in the diagnosis of Alzheimer's disease by positron emission tomography. A bis(thiosemicarbazonato)copper( ii ) complex with an appended stilbene functional group binds to amyloid-β plaques that are associated with Alzheimer's disease.
ISSN:1359-7345
1364-548X
DOI:10.1039/c0cc01175d