Modelling the Control Mechanism of the Sodium Channel in the Apical Membrane of Tight Epithelia
The unidirectional inward Na+ flux, JNaIN, passing through the sodium channel in the apical membrane of some tight epithelia depends approximately linearly on [Na]OUT as expected, but is also known to depend sensitively and inversely upon [Na] IN while the ratio of the fluxes obeys the relation JNaI...
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Veröffentlicht in: | Proceedings of the Royal Society of London. Series B, Biological sciences Biological sciences, 1982-12, Vol.217 (1206), p.111-115 |
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Sprache: | eng |
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Zusammenfassung: | The unidirectional inward Na+ flux, JNaIN, passing through the sodium channel in the apical membrane of some tight epithelia depends approximately linearly on [Na]OUT as expected, but is also known to depend sensitively and inversely upon [Na] IN while the ratio of the fluxes obeys the relation JNaIN / JNaOUT = [Na]OUT / [Na]IN In this paper it is shown that such behaviour may be simply modelled based on the assumption of only single occupancy of the channel. With use of linear flux equations the calculated flux ratio is as measured. The additional assumption of single occupancy of the channel results in the calculated values of JNaIN and JNaOUT both being multiplied by the same factor, 1— P, where P is the probability that the channel is occupied by an ion. The flux ratio thus remains unchanged but JNaIN and JNaOUT may now depend inversely upon [Na+]IN or [Na+]OUT or both, owing to the dependence of P upon these parameters. To illustrate these general conclusions, detailed calculations are made on a particular assymetrical voltage-controlled model ion channel, based upon an ordered water structure. The results obtained are shown to simulate those found experimentally for tight epithelia. |
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ISSN: | 0962-8452 0080-4649 1471-2954 2053-9193 |
DOI: | 10.1098/rspb.1982.0098 |