Opioid medication use and blood DNA methylation: epigenome-wide association meta-analysis

Opioid medication use and blood DNA methylation: epigenome-wide association meta-analysis

To identify differential methylation related to prescribed opioid use. This study examined whether blood DNA methylation, measured using Illumina arrays, differs by recent opioid medication use in four population-based cohorts. We meta-analyzed results (282 users; 10,560 nonusers) using inverse-vari...

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Veröffentlicht in:Epigenomics 2022-12, Vol.14 (23), p.1479-1492
Hauptverfasser: Lee, Mikyeong, Joehanes, Roby, McCartney, Daniel L, Kho, Minjung, Hüls, Anke, Wyss, Annah B, Liu, Chunyu, Walker, Rosie M, R Kardia, Sharon L, Wingo, Thomas S, Burkholder, Adam, Ma, Jiantao, Campbell, Archie, Wingo, Aliza P, Huan, Tianxiao, Sikdar, Sinjini, Keshawarz, Amena, Bennett, David A, Smith, Jennifer A, Evans, Kathryn L, Levy, Daniel, London, Stephanie J
Format: Artikel
Sprache:eng
Schlagworte:
Analgesics, Opioid
blood
CpG Islands
DNA Methylation
Epigenesis, Genetic
epigenetics
Epigenome
Female
Genome-Wide Association Study
Humans
Male
methylome
prescription opioids
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Zusammenfassung:To identify differential methylation related to prescribed opioid use. This study examined whether blood DNA methylation, measured using Illumina arrays, differs by recent opioid medication use in four population-based cohorts. We meta-analyzed results (282 users; 10,560 nonusers) using inverse-variance weighting. Differential methylation (false discovery rate
ISSN:1750-1911
1750-192X
DOI:10.2217/epi-2022-0353