Risk for stillbirth among pregnant individuals with SARS-CoV-2 infection varied by gestational age

Despite previous research findings on higher risks of stillbirth among pregnant individuals with SARS-CoV-2 infection, it is unclear whether the gestational timing of viral infection modulates this risk. This study aimed to examine the association between timing of SARS-CoV-2 infection during pregna...

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Veröffentlicht in:	American journal of obstetrics and gynecology 2023-09, Vol.229 (3), p.288.e1-288.e13
Hauptverfasser:	Liang, Chen, Hung, Peiyin, Zhang, Jiajia, Campbell, Berry, Ghumman, Nadia, Olatosi, Bankole, Yi, Honggang, Wilcox, Adam B., Lee, Adam M., Graves, Alexis, Anzalone, Alfred (Jerrod), Manna, Amin, Saha, Amit, Olex, Amy, Zhou, Andrea, Williams, Andrew E., Southerland, Andrew, Girvin, Andrew T., Walden, Anita, Amor, Benjamin, Bates, Benjamin, Hendricks, Brian, Patel, Brijesh, Alexander, Caleb, Bramante, Carolyn, Madlock-Brown, Charisse, Suver, Christine, Chute, Christopher, Wu, Chunlei, Schmitt, Clare, Housman, Dan, Eichmann, David A., Mazzotti, Diego, Brown, Don, Hill, Elaine, Zampino, Elizabeth, Marti, Emily Carlson, Pfaff, Emily R., French, Evan, Mariona, Federico, Prior, Fred, Sokos, George, Martin, Greg, Mehta, Hemalkumar, Liu, Hongfang, Sidky, Hythem, Hayanga, J.W. Awori, Harper, Jeremy Richard, Islam, Jessica, Ge, Jin, Gagnier, Joel, Saltz, Joel, Buse, John, Mathew, Jomol, Rutter, Joni L., McMurry, Julie A., Guinney, Justin, Starren, Justin, Crowley, Karen, Bradwell, Katie Rebecca, Walters, Kellie M., Wilkins, Ken, Murray, Kimberly, Northington, Lavance, Misquitta, Leonie, Deacy, Mariam, Bissell, Mark M., Clark, Marshall, Emmett, Mary, Adams, Meredith, Temple-O’Connor, Meredith, Morris, Michele, Qureshi, Nabeel, Safdar, Nasia, Garbarini, Nicole, Sharafeldin, Noha, Francis, Patricia A., Payne, Philip R.O., Fuentes, Rafael, Erwin-Cohen, Rebecca, Patel, Rena, Moffitt, Richard A., Zhu, Richard L., Hurley, Robert, Pyarajan, Saiju, Michael, Sam G., Bozzette, Samuel, Mallipattu, Sandeep, Vedula, Satyanarayana, Setoguchi, Soko, Hong, Stephanie S., Johnson, Steve, Bennett, Tellen D., Callahan, Tiffany, Topaloglu, Umit, Gordon, Valery, Hernandez, Wenndy, Beasley, Will, Cooper, Will, Hillegass, William
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult COVID-19 COVID-19 - epidemiology electronic health records Female Gestational Age gynecology Humans Middle Aged obstetrics Original Research: Obstetrics Placenta Pregnancy Pregnancy Complications, Infectious - epidemiology Pregnancy Outcome Retrospective Studies SARS-CoV-2 stillbirth Stillbirth - epidemiology Young Adult
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Zusammenfassung:	Despite previous research findings on higher risks of stillbirth among pregnant individuals with SARS-CoV-2 infection, it is unclear whether the gestational timing of viral infection modulates this risk. This study aimed to examine the association between timing of SARS-CoV-2 infection during pregnancy and risk of stillbirth. This retrospective cohort study used multilevel logistic regression analyses of nationwide electronic health records in the United States. Data were from 75 healthcare systems and institutes across 50 states. A total of 191,403 pregnancies of 190,738 individuals of reproductive age (15–49 years) who had childbirth between March 1, 2020 and May 31, 2021 were identified and included. The main outcome was stillbirth at ≥20 weeks of gestation. Exposures were the timing of SARS-CoV-2 infection: early pregnancy (
ISSN:	0002-9378 1097-6868 1097-6868
DOI:	10.1016/j.ajog.2023.02.022