Alzheimer's Disease: An Updated Overview of Its Genetics

Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. It is classified as familial and sporadic. The dominant familial or autosomal presentation represents 1-5% of the total number of cases. It is categorized as early onset (EOAD;

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Veröffentlicht in:	International journal of molecular sciences 2023-02, Vol.24 (4), p.3754
Hauptverfasser:	Andrade-Guerrero, Jesús, Santiago-Balmaseda, Alberto, Jeronimo-Aguilar, Paola, Vargas-Rodríguez, Isaac, Cadena-Suárez, Ana Ruth, Sánchez-Garibay, Carlos, Pozo-Molina, Glustein, Méndez-Catalá, Claudia Fabiola, Cardenas-Aguayo, Maria-Del-Carmen, Diaz-Cintra, Sofía, Pacheco-Herrero, Mar, Luna-Muñoz, José, Soto-Rojas, Luis O
Format:	Artikel
Sprache:	eng
Schlagworte:	Advertising executives Age Alzheimer Disease - genetics Alzheimer's disease Amyloid beta-Peptides - genetics Amyloid beta-protein Amyloid beta-Protein Precursor - metabolism Amyloid precursor protein Biomarkers Dementia Gene mutations Genes Genetic aspects Genetic polymorphisms Genetic variability Genome-wide association studies Genome-Wide Association Study Genomes Health risk assessment Humans Hypotheses Inflammation Mitochondria Mutation Neurodegeneration Neurodegenerative Diseases - genetics Neuropathology Oxidative stress Pathophysiology Peptides Physiology Presenilin 1 Presenilin 2 Presenilin-1 - genetics Presenilin-2 - genetics Proteins Review Risk factors Target marketing Tau protein Therapeutic targets β-Amyloid
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Beschreibung
Zusammenfassung:	Alzheimer's disease (AD) is the most common neurodegenerative disease in the world. It is classified as familial and sporadic. The dominant familial or autosomal presentation represents 1-5% of the total number of cases. It is categorized as early onset (EOAD;
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms24043754