Multifaceted Nature of DNA Polymerase θ

DNA polymerase θ belongs to the A family of DNA polymerases and plays a key role in DNA repair and damage tolerance, including double-strand break repair and DNA translesion synthesis. Pol θ is often overexpressed in cancer cells and promotes their resistance to chemotherapeutic agents. In this revi...

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Veröffentlicht in:	International journal of molecular sciences 2023-02, Vol.24 (4), p.3619
Hauptverfasser:	Kruchinin, Alexander A, Makarova, Alena V
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Chemotherapy Damage tolerance Deoxyribonucleic acid DNA DNA biosynthesis DNA Damage DNA polymerase DNA Polymerase theta DNA polymerases DNA Repair DNA Replication DNA-directed DNA polymerase DNA-Directed DNA Polymerase - metabolism Double-strand break repair Fingers & toes Genes Genomes Genomics Radiation Review
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