Multifaceted Nature of DNA Polymerase θ

DNA polymerase θ belongs to the A family of DNA polymerases and plays a key role in DNA repair and damage tolerance, including double-strand break repair and DNA translesion synthesis. Pol θ is often overexpressed in cancer cells and promotes their resistance to chemotherapeutic agents. In this revi...

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Veröffentlicht in:	International journal of molecular sciences 2023-02, Vol.24 (4), p.3619
Hauptverfasser:	Kruchinin, Alexander A, Makarova, Alena V
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Chemotherapy Damage tolerance Deoxyribonucleic acid DNA DNA biosynthesis DNA Damage DNA polymerase DNA Polymerase theta DNA polymerases DNA Repair DNA Replication DNA-directed DNA polymerase DNA-Directed DNA Polymerase - metabolism Double-strand break repair Fingers & toes Genes Genomes Genomics Radiation Review
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Beschreibung
Zusammenfassung:	DNA polymerase θ belongs to the A family of DNA polymerases and plays a key role in DNA repair and damage tolerance, including double-strand break repair and DNA translesion synthesis. Pol θ is often overexpressed in cancer cells and promotes their resistance to chemotherapeutic agents. In this review, we discuss unique biochemical properties and structural features of Pol θ, its multiple roles in protection of genome stability and the potential of Pol θ as a target for cancer treatment.
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms24043619