Global longitudinal strain: an early marker for cardiotoxicity in patients treated for breast cancer

Global longitudinal strain: an early marker for cardiotoxicity in patients treated for breast cancer

Background Patients treated with anthracyclines and trastuzumab are at increased risk of developing heart failure. Early diagnosis and treatment may prevent irreversible left ventricular (LV) dysfunction. This study investigates whether subclinical deterioration of global longitudinal strain (GLS) i...

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Veröffentlicht in:Netherlands heart journal 2023-03, Vol.31 (3), p.103-108
Hauptverfasser: van der Linde, D., van Hagen, I., Veen, K., Zuetenhorst, H., van Dalen, B.
Format: Artikel
Sprache:eng
Schlagworte:
Breast cancer
Cancer therapies
Cardiology
Cardiotoxicity
Chemotherapy
Ejection fraction
Heart failure
Medical Education
Medicine
Medicine & Public Health
Monoclonal antibodies
Normal distribution
Original
Original Article
Patients
Targeted cancer therapy
Values
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Zusammenfassung:Background Patients treated with anthracyclines and trastuzumab are at increased risk of developing heart failure. Early diagnosis and treatment may prevent irreversible left ventricular (LV) dysfunction. This study investigates whether subclinical deterioration of global longitudinal strain (GLS) is a more reliable early predictor for LV dysfunction than three-dimensional (3D) LV ejection fraction (LVEF). Methods Adult patients receiving anthracyclines and trastuzumab for breast cancer who had serial echocardiographic follow-up were included in this retrospective study. The primary endpoint was the necessity to temporarily pause chemo- or immunotherapy due to declining LVEF (decline in 3D LVEF of > 10 percentage points to
ISSN:1568-5888
1876-6250
DOI:10.1007/s12471-022-01734-3