Harnessing the Plasma Proteome to Mirror Current and Predict Future Cardiac Remodeling After Myocardial Infarction

To identify plasma proteins that mirror current and predict future remodeling after myocardial infarction (MI), we retrospectively interrogated plasma proteomes of day (D)0 control ( n = 16) and D3 MI ( n = 15) from C57BL/6 J mice (20 ± 1 months). A total of 165 unique proteins were correlated with cardiac physiology variables. We prospectively tested the hypothesis that candidates identified retrospectively would predict cardiac physiology at an extended timepoint (D7 MI) in a second cohort of mice ( n = 4 ± 1 months). We also examined human plasma from healthy controls ( n = 18) and patients 48 h after presentation for MI ( n = 41). Retrospectively, we identified 5 strong reflectors of remodeling (all r ≥ 0.60 and p