Regioselective intramolecular cyclization of o -alkynyl arylamines with the in situ formation of ArXCl to construct poly-functionalized 3-selenylindoles
In this article, a practical and metal-free method for the synthesis of poly-functionalized 3-selenyl/sulfenyl/telluriumindoles from -alkynyl arylamines has been achieved. In this protocol, the formation of selenenyl chloride, sulfenyl chloride or tellurenyl chloride is considered as the key interme...
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Veröffentlicht in: | RSC advances 2023-02, Vol.13 (9), p.6210-6216 |
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Hauptverfasser: | , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | In this article, a practical and metal-free method for the synthesis of poly-functionalized 3-selenyl/sulfenyl/telluriumindoles from
-alkynyl arylamines has been achieved. In this protocol, the
formation of selenenyl chloride, sulfenyl chloride or tellurenyl chloride is considered as the key intermediate and the 3-selenyl/sulfenyl/telluriumindoles can be obtained in good to excellent yields. Furthermore, the product 2-phenyl-3-(phenylselanyl)-1-tosyl-1
-indole can be selectively oxidized to compounds 2-phenyl-3-(phenylseleninyl)-1-tosyl-1
-indole and 2-phenyl-3-(phenylselenonyl)-1-tosyl-1
-indole in good yields. |
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ISSN: | 2046-2069 2046-2069 |
DOI: | 10.1039/d3ra00030c |