Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Person With HIV
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial SARS-CoV-2 evolution o...
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| Veröffentlicht in: | Open Forum Infectious Diseases 2023-02, Vol.10 (2), p.ofad054-ofad054 |
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| container_issue | 2 |
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| container_title | Open Forum Infectious Diseases |
| container_volume | 10 |
| creator | Khosravi, Dara Soloff, Hannah Langsjoen, Rose M Bombin, Andrei Kelley, Colleen F Ray, Susan M Gunthel, Clifford J Zanoni, Brian C Nguyen, Phuong-Vi Waggoner, Jesse J Wang, Yun F Cantos, Valeria D Piantadosi, Anne |
| description | Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial SARS-CoV-2 evolution occurred, including the emergence of 2 mutations associated with escape from the monoclonal antibody cocktail received. |
| doi_str_mv | 10.1093/ofid/ofad054 |
| format | Article |
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial SARS-CoV-2 evolution occurred, including the emergence of 2 mutations associated with escape from the monoclonal antibody cocktail received.</description><identifier>ISSN: 2328-8957</identifier><identifier>EISSN: 2328-8957</identifier><identifier>DOI: 10.1093/ofid/ofad054</identifier><identifier>PMID: 36820315</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Brief Report ; Coronaviruses ; Emtricitabine ; Health aspects ; Highly active antiretroviral therapy ; HIV (Viruses) ; HIV patients ; Infection ; Monoclonal antibodies</subject><ispartof>Open Forum Infectious Diseases, 2023-02, Vol.10 (2), p.ofad054-ofad054</ispartof><rights>The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. 2023</rights><rights>The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America.</rights><rights>COPYRIGHT 2023 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-9020ffdcc740e1d59871ddac014aba9fb974107129585b74d96b7443fb8d47993</citedby><cites>FETCH-LOGICAL-c483t-9020ffdcc740e1d59871ddac014aba9fb974107129585b74d96b7443fb8d47993</cites><orcidid>0000-0003-3422-5315 ; 0000-0002-5942-1534 ; 0000-0001-5611-0119</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938522/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9938522/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1604,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36820315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Khosravi, Dara</creatorcontrib><creatorcontrib>Soloff, Hannah</creatorcontrib><creatorcontrib>Langsjoen, Rose M</creatorcontrib><creatorcontrib>Bombin, Andrei</creatorcontrib><creatorcontrib>Kelley, Colleen F</creatorcontrib><creatorcontrib>Ray, Susan M</creatorcontrib><creatorcontrib>Gunthel, Clifford J</creatorcontrib><creatorcontrib>Zanoni, Brian C</creatorcontrib><creatorcontrib>Nguyen, Phuong-Vi</creatorcontrib><creatorcontrib>Waggoner, Jesse J</creatorcontrib><creatorcontrib>Wang, Yun F</creatorcontrib><creatorcontrib>Cantos, Valeria D</creatorcontrib><creatorcontrib>Piantadosi, Anne</creatorcontrib><title>Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Person With HIV</title><title>Open Forum Infectious Diseases</title><addtitle>Open Forum Infect Dis</addtitle><description>Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial SARS-CoV-2 evolution occurred, including the emergence of 2 mutations associated with escape from the monoclonal antibody cocktail received.</description><subject>Brief Report</subject><subject>Coronaviruses</subject><subject>Emtricitabine</subject><subject>Health aspects</subject><subject>Highly active antiretroviral therapy</subject><subject>HIV (Viruses)</subject><subject>HIV patients</subject><subject>Infection</subject><subject>Monoclonal antibodies</subject><issn>2328-8957</issn><issn>2328-8957</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9kcFrHCEUxofS0IQkt56Lt_bQTXV0Vr0UlmXTBFJSmrQ9iqNvEsuMTtVZ2P-gf3bc7DaklyA8H77f9_Hkq6q3BJ8RLOmn0Dlbira4Ya-qo5rWYiZkw18_6w-r05R-Y4wJwQ3m8k11SOeixpQ0R9XfG1hDBLQwUwb0HdLoos4hbtDNxtsYBkDLEIPXaxenhGq0Wod-yi54pL1Fq2T0COi8gIUbWuf14-xr8MH0Rdajhc-uDXaDbiPoPIDPyBUx-gYxFfKXy_fo4vLnSXXQ6T7B6f4-rn6cr26XF7Or6y-Xy8XVzDBB80ziGnedNYYzDMQ2UnBirTaYMN1q2bWSM4I5qWUjmpYzK-elMtq1wjIuJT2uPu98x6kdwJqyT9S9GqMbdNyooJ36f-LdvboLa1W0oqnrYvBhbxDDnwlSVoNLBvpeewhTUjXnkjIxp6ygZzv0TvegnO9CcTTlWBicCR46V94XnFPByJxvl_u4E5gYUorQPe1FsNoGrraBq33gBX_3_C9P8L94C_B-B4RpfNnqAbLbt5M</recordid><startdate>20230201</startdate><enddate>20230201</enddate><creator>Khosravi, Dara</creator><creator>Soloff, Hannah</creator><creator>Langsjoen, Rose M</creator><creator>Bombin, Andrei</creator><creator>Kelley, Colleen F</creator><creator>Ray, Susan M</creator><creator>Gunthel, Clifford J</creator><creator>Zanoni, Brian C</creator><creator>Nguyen, Phuong-Vi</creator><creator>Waggoner, Jesse J</creator><creator>Wang, Yun F</creator><creator>Cantos, Valeria D</creator><creator>Piantadosi, Anne</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-3422-5315</orcidid><orcidid>https://orcid.org/0000-0002-5942-1534</orcidid><orcidid>https://orcid.org/0000-0001-5611-0119</orcidid></search><sort><creationdate>20230201</creationdate><title>Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Person With HIV</title><author>Khosravi, Dara ; Soloff, Hannah ; Langsjoen, Rose M ; Bombin, Andrei ; Kelley, Colleen F ; Ray, Susan M ; Gunthel, Clifford J ; Zanoni, Brian C ; Nguyen, Phuong-Vi ; Waggoner, Jesse J ; Wang, Yun F ; Cantos, Valeria D ; Piantadosi, Anne</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-9020ffdcc740e1d59871ddac014aba9fb974107129585b74d96b7443fb8d47993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Brief Report</topic><topic>Coronaviruses</topic><topic>Emtricitabine</topic><topic>Health aspects</topic><topic>Highly active antiretroviral therapy</topic><topic>HIV (Viruses)</topic><topic>HIV patients</topic><topic>Infection</topic><topic>Monoclonal antibodies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Khosravi, Dara</creatorcontrib><creatorcontrib>Soloff, Hannah</creatorcontrib><creatorcontrib>Langsjoen, Rose M</creatorcontrib><creatorcontrib>Bombin, Andrei</creatorcontrib><creatorcontrib>Kelley, Colleen F</creatorcontrib><creatorcontrib>Ray, Susan M</creatorcontrib><creatorcontrib>Gunthel, Clifford J</creatorcontrib><creatorcontrib>Zanoni, Brian C</creatorcontrib><creatorcontrib>Nguyen, Phuong-Vi</creatorcontrib><creatorcontrib>Waggoner, Jesse J</creatorcontrib><creatorcontrib>Wang, Yun F</creatorcontrib><creatorcontrib>Cantos, Valeria D</creatorcontrib><creatorcontrib>Piantadosi, Anne</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Open Forum Infectious Diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Khosravi, Dara</au><au>Soloff, Hannah</au><au>Langsjoen, Rose M</au><au>Bombin, Andrei</au><au>Kelley, Colleen F</au><au>Ray, Susan M</au><au>Gunthel, Clifford J</au><au>Zanoni, Brian C</au><au>Nguyen, Phuong-Vi</au><au>Waggoner, Jesse J</au><au>Wang, Yun F</au><au>Cantos, Valeria D</au><au>Piantadosi, Anne</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Person With HIV</atitle><jtitle>Open Forum Infectious Diseases</jtitle><addtitle>Open Forum Infect Dis</addtitle><date>2023-02-01</date><risdate>2023</risdate><volume>10</volume><issue>2</issue><spage>ofad054</spage><epage>ofad054</epage><pages>ofad054-ofad054</pages><issn>2328-8957</issn><eissn>2328-8957</eissn><abstract>Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial SARS-CoV-2 evolution occurred, including the emergence of 2 mutations associated with escape from the monoclonal antibody cocktail received.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>36820315</pmid><doi>10.1093/ofid/ofad054</doi><orcidid>https://orcid.org/0000-0003-3422-5315</orcidid><orcidid>https://orcid.org/0000-0002-5942-1534</orcidid><orcidid>https://orcid.org/0000-0001-5611-0119</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 2328-8957 |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford Journals Open Access Collection; PubMed Central |
| subjects | Brief Report Coronaviruses Emtricitabine Health aspects Highly active antiretroviral therapy HIV (Viruses) HIV patients Infection Monoclonal antibodies |
| title | Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Person With HIV |
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