Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Person With HIV

Severe Acute Respiratory Syndrome Coronavirus 2 Evolution and Escape From Combination Monoclonal Antibody Treatment in a Person With HIV

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial SARS-CoV-2 evolution o...

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Veröffentlicht in:Open Forum Infectious Diseases 2023-02, Vol.10 (2), p.ofad054-ofad054
Hauptverfasser: Khosravi, Dara, Soloff, Hannah, Langsjoen, Rose M, Bombin, Andrei, Kelley, Colleen F, Ray, Susan M, Gunthel, Clifford J, Zanoni, Brian C, Nguyen, Phuong-Vi, Waggoner, Jesse J, Wang, Yun F, Cantos, Valeria D, Piantadosi, Anne
Format: Artikel
Sprache:eng
Schlagworte:
Brief Report
Coronaviruses
Emtricitabine
Health aspects
Highly active antiretroviral therapy
HIV (Viruses)
HIV patients
Infection
Monoclonal antibodies
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Zusammenfassung:Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) escape from combination monoclonal antibody treatment is rarely reported. We describe an immunocompromised individual with human immunodeficiency virus and persistent SARS-CoV-2 infection in whom substantial SARS-CoV-2 evolution occurred, including the emergence of 2 mutations associated with escape from the monoclonal antibody cocktail received.
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofad054