Pneumocystis jirovecii Infections Among COVID-19 Patients: A Case Series and Literature Review

Pneumocystis jirovecii Infections Among COVID-19 Patients: A Case Series and Literature Review

Abstract Background Pneumocystis jirovecii pneumonia (PCP) is a serious, emerging complication of coronavirus disease 2019 (COVID-19). Methods We performed a systematic review of published cases. We describe 6 new cases of PCP/COVID-19 coinfection. Among our cases (n = 6) and those in the literature...

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Veröffentlicht in:Open Forum Infectious Diseases 2023-02, Vol.10 (2), p.ofad043
Hauptverfasser: Amstutz, Paul, Bahr, Nathan C, Snyder, Karen, Shoemaker, D Matthew
Format: Artikel
Sprache:eng
Schlagworte:
Antifungal agents
Apixaban
Bacterial pneumonia
Cancer
Chemotherapy
Comorbidity
Coronaviruses
Corticosteroids
Health aspects
HIV infection
Immunotherapy
Major
Mortality
Pneumonia
Risk factors
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Zusammenfassung:Abstract Background Pneumocystis jirovecii pneumonia (PCP) is a serious, emerging complication of coronavirus disease 2019 (COVID-19). Methods We performed a systematic review of published cases. We describe 6 new cases of PCP/COVID-19 coinfection. Among our cases (n = 6) and those in the literature (n = 69) with available data, the median age (interquartile range [IQR]) was 59 (44–77) years (n = 38), 72% (47/65) were male, and the mortality rate was 30.9% (21/68). Results Long-term corticosteroid use was noted in 45.1% (23/51), advanced HIV infection (defined as a CD4 count
ISSN:2328-8957
2328-8957
DOI:10.1093/ofid/ofad043