Impact of preexisting type 2 diabetes mellitus and antidiabetic drugs on all-cause and cause-specific mortality among Medicaid-insured women diagnosed with breast cancer

Impact of preexisting type 2 diabetes mellitus and antidiabetic drugs on all-cause and cause-specific mortality among Medicaid-insured women diagnosed with breast cancer

•Among women with breast cancer, those with type 2 diabetes had higher mortality hazard than nondiabetics.•Women prescribed sulfonylurea or insulin had an elevated mortality hazard compared to women prescribed metformin.•Among women 50 years of age and older with breast cancer, those with type 2 dia...

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Veröffentlicht in:Cancer epidemiology 2020-06, Vol.66, p.101710-101710, Article 101710
Hauptverfasser: Lawrence, Wayne R., Hosler, Akiko S., Gates Kuliszewski, Margaret, Leinung, Matthew C., Zhang, Xiuling, Schymura, Maria J., Boscoe, Francis P.
Format: Artikel
Sprache:eng
Schlagworte:
Age
Antidiabetics
Breast cancer
Breast Neoplasms - complications
Breast Neoplasms - mortality
Cancer
Cancer registry
Cancer therapies
Cardiovascular
Cardiovascular disease
Cause of Death - trends
Chronology
Confidence intervals
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - epidemiology
Diagnosis
Epidemiology
Female
Glucose-lowering drugs
Government programs
Health hazards
Health risk assessment
Humans
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
Insulin
Medicaid
Medicaid - standards
Menopause
Metformin
Middle Aged
Minority & ethnic groups
Mortality
Post-menopause
Statistical analysis
Subgroups
Sulfonylurea
United States
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Zusammenfassung:•Among women with breast cancer, those with type 2 diabetes had higher mortality hazard than nondiabetics.•Women prescribed sulfonylurea or insulin had an elevated mortality hazard compared to women prescribed metformin.•Among women 50 years of age and older with breast cancer, those with type 2 diabetes had a 47% higher mortality hazard. We investigated the influence preexisting type 2 diabetes mellitus (T2DM) and antidiabetic drugs have on all-cause and cause-specific mortality among Medicaid-insured women diagnosed with breast cancer. 9221 women aged
ISSN:1877-7821
1877-783X
DOI:10.1016/j.canep.2020.101710