Acute Pancreatitis as a First Presentation of Granulomatosis With Polyangiitis

Granulomatosis with polyangiitis (GPA) is a rare necrotizing antineutrophil cytoplasmic antibody-associated vasculitis characterized by inflammation in small-sized arteries. Gastrointestinal involvement is exceedingly rare in GPA. Here, we present a case of recurrent acute pancreatitis as the initia...

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Veröffentlicht in:ACG case reports journal 2023-02, Vol.10 (2), p.e00986-e00986
Hauptverfasser: Youssef, Michael, Sedarous, Mary, Grin, Andrea, Chung, Andrew, Hookey, Lawrence
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Sprache:eng
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Zusammenfassung:Granulomatosis with polyangiitis (GPA) is a rare necrotizing antineutrophil cytoplasmic antibody-associated vasculitis characterized by inflammation in small-sized arteries. Gastrointestinal involvement is exceedingly rare in GPA. Here, we present a case of recurrent acute pancreatitis as the initial presentation of GPA. The diagnosis was made based on radiological and pathological findings of acute pancreatitis in conjunction with positive anti-PR3 antibody which is strongly associated with GPA. Systemic vasculitides are rare but important to consider in cases of idiopathic acute pancreatitis. Early diagnosis and therapy allow for high rates of remission and improved survival rates.
ISSN:2326-3253
2326-3253
DOI:10.14309/crj.0000000000000986