Multisystem inflammatory syndrome in children (MIS‐C) and the prothrombotic state: Coagulation profiles and rotational thromboelastometry in a MIS‐C cohort

Background Adults infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) have had high rates of thrombosis. A novel condition in children infected with SARS‐CoV‐2, multisystem inflammatory syndrome in children (MIS‐C), has limited data on their prothrombotic state or need for thr...

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Veröffentlicht in:Journal of thrombosis and haemostasis 2021-07, Vol.19 (7), p.1764-1770
Hauptverfasser: Al‐Ghafry, Maha, Vagrecha, Anshul, Malik, Marium, Levine, Chana, Uster, Eliza, Aygun, Banu, Appiah‐Kubi, Abena, Vlachos, Adrianna, Capone, Christine A., Rajan, Sujatha, Palumbo, Nancy, Misra, Nilanjana, Mitchell, Elizabeth C., Wolfe, Lawrence C., Lipton, Jeffrey M., Shore‐Lesserson, Linda, Acharya, Suchitra S.
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Sprache:eng
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Zusammenfassung:Background Adults infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) have had high rates of thrombosis. A novel condition in children infected with SARS‐CoV‐2, multisystem inflammatory syndrome in children (MIS‐C), has limited data on their prothrombotic state or need for thromboprophylaxis. Objectives We aimed to analyze the prothrombotic state using coagulation profiles, rotational thromboelastometry (ROTEM) parameters and clinical outcomes, to determine if this could aid in risk stratification for thromboprophylaxis. Methods This analysis included patients (
ISSN:1538-7933
1538-7836
1538-7836
DOI:10.1111/jth.15340