Chemoselective oxidation of alcohols in the presence of amines using an oxoammonium salt

Chemoselective oxidation of alcohols in the presence of amines using an oxoammonium salt

The oxidation of alcohols in the presence of reactive amines employing the commercially available oxoammonium cation, “Bobbitt's salt” is described. The oxidation is accomplished under acidic conditions and subsequent treatment with a suitable base affords a convenient one-pot method to access...

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Veröffentlicht in:Tetrahedron 2023-01, Vol.131, p.133226, Article 133226
Hauptverfasser: Lewis, Stephonda G., Dadum, Abra G., McLean, David, Buenavista, Jhennalin, Myers, Jaileen, Lambert, Kyle M., Fair, Justin D.
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols
Amines
Bobbitt's salt
Imines
Oxidation
Oxoammonium salts
Protecting groups
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Zusammenfassung:The oxidation of alcohols in the presence of reactive amines employing the commercially available oxoammonium cation, “Bobbitt's salt” is described. The oxidation is accomplished under acidic conditions and subsequent treatment with a suitable base affords a convenient one-pot method to access imines in good to excellent isolated yields (74–99%). [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2022.133226