Effects of Lactobacillus reuteri MG5346 on Receptor Activator of Nuclear Factor-Kappa B Ligand (RANKL)-Induced Osteoclastogenesis and Ligature-Induced Experimental Periodontitis Rats

Effects of Lactobacillus reuteri MG5346 on Receptor Activator of Nuclear Factor-Kappa B Ligand (RANKL)-Induced Osteoclastogenesis and Ligature-Induced Experimental Periodontitis Rats

Effects of culture supernatants of MG5346 (CS-MG5346) on receptor activator of nuclear factor-kappa B ligand (RANKL)-induced osteoclastogenesis were examined. CS-MG5346 treatment up to 400 μg/mL significantly reduced tartrate-resistant acid-phosphatase (TRAP) activity, the phenotype biomarker of ost...

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Veröffentlicht in:Food science of animal resources 2023-01, Vol.43 (1), p.157-169
Hauptverfasser: Jeong, Yu-Jin, Jung, Jae-In, Kim, YongGyeong, Kang, Chang-Ho, Imm, Jee-Young
Format: Artikel
Sprache:eng
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Zusammenfassung:Effects of culture supernatants of MG5346 (CS-MG5346) on receptor activator of nuclear factor-kappa B ligand (RANKL)-induced osteoclastogenesis were examined. CS-MG5346 treatment up to 400 μg/mL significantly reduced tartrate-resistant acid-phosphatase (TRAP) activity, the phenotype biomarker of osteoclast, without affecting cell viability. CS-MG5346 inhibited the expression of osteoclast specific transcriptional factors (c-fos and nuclear factor-activated T cells c1) and their target genes ( , , ) in a dose-dependent manner (p
ISSN:2636-0772
2636-0780
DOI:10.5851/kosfa.2022.e68